Soulless unfolds in the fictional town of Bell's End, a place with a curse hanging over it since its 1700 founding. After a young woman is killed in a car accident, her body goes missing en route to the hospital. Days later she is discovered behind a local hotel, alive. Meanwhile, word of her reanimation gets back to the DOD, where decades earlier, a failed covert research project on tissue regeneration was conducted on the woman's mother. The DOD launches a relentless effort to capture her as she quickly learns that trying to return to the land of the living threatens to destroy the people she loves most.

"She defied nature. Now, she's hunted."