Charming Sinners was a stilted adaptation of Somerset Maugham's play The Constant Wife. Robert Miles (Clive Brook) starts the ball rolling when he falls in love with Anne-Marie Whitley (Mary Nolan), the best friend of his own wife Kathryn (Ruth Chatterton). In retaliation, Kathryn begins a flirtation with her former boyfriend Karl Kraley (William Powell). After reels and reels of verbal fencing, the status quo is re-established, and Robert and Kathryn are reunited.

"It takes a smart woman to outwit a clever man — especially when that man is her husband!"